Squamous cell skin cancer
Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main types of skin cancer along with basal cell cancer, and melanoma.[10] It usually presents as a hard lump with a scaly top but can also form an ulcer.[1] Onset is often over months.[4] Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer.[11]
The greatest risk factor is high total exposure to ultraviolet radiation from the Sun.[2] Other risks include prior scars, chronic wounds, actinic keratosis, lighter skin, Bowen’s disease, arsenic exposure, radiation therapy, poor immune system function, previous basal cell carcinoma, and HPV infection.[2][12] Risk from UV radiation is related to total exposure, rather than early exposure.[13] Tanning beds are becoming another common source of ultraviolet radiation.[13] It begins from squamous cells found within the skin.[14] Diagnosis is often based on skin examination and confirmed by tissue biopsy.[2][3]
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing squamous-cell skin cancer.[5][6] Treatment is typically by surgical removal.[2] This can be by simple excision if the cancer is small otherwise Mohs surgery is generally recommended.[2] Other options may include application of cold and radiation therapy.[7] In the cases in which distant spread has occurred chemotherapy or biologic therapy may be used.[7]
As of 2015, about 2.2 million people have cSCC at any given time.[8] It makes up about 20% of all skin cancer cases.[15] About 12% of males and 7% of females in the United States developed cSCC at some point in time.[2] While prognosis is usually good, if distant spread occurs five-year survival is ~34%.[4][5] In 2015 it resulted in about 51,900 deaths globally.[9] The usual age at diagnosis is around 66.[4] Following the successful treatment of one case of cSCC people are at high risk of developing further cases.[2]
Edmonds
Edmonds is a city in Snohomish County, Washington, United States, and is a Northern Suburb of Seattle located 11 miles (18 km) north of the city. Edmonds has a view of Puget Sound and both the Olympic Mountains and Cascade Range. The third most populous city in Snohomish County after Everett and Marysville, the population was 39,709 according to the 2010 census and the estimated population in 2015 was 40,490.[3] Based on per capita income, one of the more reliable measures of affluence, Edmonds ranks 20th of 281 areas in the state of Washington.[5]
Edmonds is a port in the Washington State Ferries system. Currently, the only ferry from Edmonds is a run to Kingston, Washington; in the past, there have been much longer routes from Edmonds to Port Townsend, Washington.[6]
Edmonds is the oldest incorporated city in Snohomish County. Logger George Brackett founded Edmonds in 1890, naming the city either for Vermont Sen. George Franklin Edmunds[7] or in association with the nearby Point Edmund, named by Charles Wilkes in 1841 and later changed to Point Edwards.[8] Brackett came to the future site of Edmonds while paddling a canoe north of Seattle, searching for timber. When a gust of wind hit his canoe, Brackett beached in a location later called “Brackett’s Landing”.[9]
The town was named Edmonds in 1884, but was not incorporated until 1890 as an official “village fourth class” of Snohomish County. In that same year, Brackett sold 455 acres (1.84 km2) to the Minneapolis Realty and Investment Company. The town was plotted and a wharf was added along the waterfront. Modest houses and commercial structures sprouted up with a row of shingle mills dominating the cityscape.